Miss Fortune is not very strong in the early game but she does have a lot of poke damage with her Q. Watch your positioning and avoid standing behind minions when possible.
Post 6, stand in the middle of the lane at all times to make it easier for you to get out of her Ultimate R when she channels it. If you stand near a wall, it will be harder for you to escape the damage.
When paired with a hard engage Support, do not stand too far forward as the enemy Support may engage and set up the Miss Fortune for a good Ultimate R. If you have a dodge, don’t use it when her Ultimate R is up.
Do not fight Miss Fortune and her team inside the jungle as her Ultimate R will cover the entire pathway which will allow her to deal tons of damage to your whole team.
As soon as Miss Fortune channels her Ultimate R, try to cancel it by CC’ing her. If you can cancel it quickly, her damage output will be very low.
Do not group to close together as Miss Fortune will be able to hit your whole team with her Ultimate R. Splitting up isn’t a bad idea when trying to team fight.
Once Miss Fortune hits level 6, her kill pressure increases thanks to her Ultimate R and its damage.
In team fights, Miss Fortune truly shines as her Ultimate R can deal tons of damage if she uses it in a safe place. Disengage as soon as she channels her Ultimate R.
At level 9, Miss Fortune’s Q will deal tons of damage if it hits you. Watch your positioning and make sure you’re never directly behind a minion.