Scales extremely well into the late game and can single-handedly carry a game if the game lasts for that long. She can even duel enemy champs due to her Q mobility.
Extreme mobility allows her to both dodge skillshots, and play defensively at the same time. This can be extremely obnoxious for the enemy, especially when Vayne is using her Ultimate R.
Her W is a real game-changer for her as she can use it to completely win extended trades against other laners. It also allows her to cut through tanks’ health bar like butter.
Mechanically challenging to play as one mistake/misstep can get her killed immediately. Crowd control is her mortal enemy and her enemies can get rid of her as soon as she is crowd controlled.
Quite vulnerable in team fights without her Ultimate R. She needs the invisibility in order to juke her enemies, otherwise, she can’t really do much other than completely rely on her team.
She is very weak during the early game and hence can easily be shut down with constant ganks from the enemy team. Her short-range doesn’t help her either so the enemy can camp this lane with ease.
0 - 15 min
Play safe for the first few levels. You need time to come online and you shouldn’t be fighting unless you have a clear early advantage.
Once you have a few levels under your belt, you can start to play aggressive and look for aggressive plays. However, you will rely on your Support to do the heavy lifting early on.
After destroying the bottom lane tower, rotate to the mid lane and try to take that tower. This will open up the map and give your team a gold lead.
15 - 25 min
Try and stick with your Support throughout the mid-game. You’re quite vulnerable and easy to kill if you’re on your own. By staying with your Support, your survivability will increase.
Continue picking up farm in the side lanes when no team fights are occurring, but spend as little time away from your team. You need gold and XP to buy items and if you fall behind, it will be unlikely that you’ll be able to dish out damage in fights.
Look for picks with your Support/Jungler to get kills and increase your lead. If you kill a key target, you could make the call for Baron.
Just like in the mid-game, you should stick with your Support throughout the later parts of the game. Do not go around the map alone as you will die easily.
Do not play super aggressive in team fights. Just kite and auto-attack the nearest enemy champion. If you walk too far forward, the enemy will focus you and take you down.
Continue to kite in team fights and consistently adapt your positioning. Avoid standing still in fights as you’ll be an easy target.
Vayne needs a lot of time to scale due to the nature of her kit. The farther she goes into the game, the greater her chances of solo carrying her team to victory.
Level six is a massive early game spike as she can now look for aggressive all-ins on the enemy. It is effortless for Vayne to bamboozle the enemies now due to her invisibility.
The first item component will surely give Vayne a massive boost in dueling. She will need to use the lane brushes to ensure that she can compensate for her short range.
Her first ability will be maxed out at level nine. From this point, she will start hitting like a truck as her Q will be up very quickly in the game.
Getting two points in her Ultimate R will cause her to spike again. It will help her a lot in team fights, especially when the enemy team is filled with heavy CC champions.
She will have her core items by now, which means that she will deal a respectable amount of damage. She can even duel enemies and won't need her Support to babysit her if she masters her Q usage.
Vayne shines during the late game as she can run down enemies due to her Q and W. All she needs to do is to avoid getting CC'd.
A fully maxed out Ultimate R will give a massive power spike to Vayne. This is absolutely necessary to win the game and will allow Vayne to dish out tons of damage.
Vayne will have multiple items by now, which means that she will be hitting enemies like a truck. A defensive item should allow her to solidify her position as the primary carry of the team.