Scales extremely well into the late game and can single-handedly carry a game if the game lasts for that long. She can even duel enemy champs due to her Q mobility.
Extreme mobility allows her to both dodge skillshots, and play defensively at the same time. This can be extremely obnoxious for the enemy, especially when Vayne is using her Ultimate R.
Her W is a real game-changer for her as she can use it to completely win extended trades against other laners. It also allows her to cut through tanks’ health bar like butter.
Mechanically challenging to play as one mistake/misstep can get her killed immediately. Crowd control is her mortal enemy and her enemies can get rid of her as soon as she is crowd controlled.
Quite vulnerable in team fights without her Ultimate R. She needs the invisibility in order to juke her enemies, otherwise, she can’t really do much other than completely rely on her team.
She is very weak during the early game and hence can easily be shut down with constant ganks from the enemy team. Her short-range doesn’t help her either so the enemy can camp this lane with ease.
0 - 15 min
Play safe for the first few levels. You need time to come online and you shouldn’t be fighting unless you have a clear early advantage.
Once you have a few levels under your belt, you can start to play aggressive and look for aggressive plays. However, you will rely on your Support to do the heavy lifting early on.
After destroying the bottom lane tower, rotate to the mid lane and try to take that tower. This will open up the map and give your team a gold lead.
15 - 25 min
Try and stick with your Support throughout the mid-game. You’re quite vulnerable and easy to kill if you’re on your own. By staying with your Support, your survivability will increase.
Continue picking up farm in the side lanes when no team fights are occurring, but spend as little time away from your team. You need gold and XP to buy items and if you fall behind, it will be unlikely that you’ll be able to dish out damage in fights.
Look for picks with your Support/Jungler to get kills and increase your lead. If you kill a key target, you could make the call for Baron.
Just like in the mid-game, you should stick with your Support throughout the later parts of the game. Do not go around the map alone as you will die easily.
Do not play super aggressive in team fights. Just kite and auto-attack the nearest enemy champion. If you walk too far forward, the enemy will focus you and take you down.
Continue to kite in team fights and consistently adapt your positioning. Avoid standing still in fights as you’ll be an easy target.
Vayne's initial power spike is when she hits level two and has access to her Q and W. She can now go for short burst trades with her W stacking ability.
Getting her E should give her a reliable form of disengagement from enemies who like to dive her. She can also extend the CC duration on an enemy if they are positioned near a wall.
Procuring her Ultimate R should be her most potent power spike during this stage of the game. The Ultimate R invisibility can easily allow her to dodge CC abilities and completely baffle enemies.
Getting her core items should help her immensely during fights. Combined with her Q, she can quickly kill any enemy team member if she can dodge their CC abilities.
Her W will be handy during this phase of the game. This is because it can help her shred through tanks with no effort at all. Playing front to back will be optimal for her.
She will want to fight around open areas. It will help Vayne kite quickly and dish out a lot of damage in a short time. She may need to use her Flash in emergencies.
Vayne should be a powerhouse during this phase of the game. She can efficiently run down any enemy who stands in her path as long as she doesn't get CC'd.
Getting a QSS should be of paramount importance during this phase of the game. It allows her to play more freely and be safe from CC based abilities.
Spacing will be vital to Vayne's ability to play the game out. This is the game phase where the enemies have their abilities on a very short cooldown, and hence Vayne's nimbleness will determine if she is useful or a deadweight.
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