Can dish out a lot of burst damage while moving around quickly during team fights. This makes it very hard to catch him and kill him in a team fight.
Great objective control due to his Ultimate 
R. It can allow him to transition from a Dragon to Baron almost immediately. He can also pull backdoors off with this ability.
The CC on his 
W allows him to set plays for both himself and his team. This can be really effective if he manages to CC a high priority target, and get rid of them quickly.
Can’t really do much during the early game, especially if he is against something with hard CC or if he is getting camped.
Extremely item reliant and won’t dish out a lot of damage if he was set behind during the early and mid game.
His Ultimate R changes the positioning of him and anyone inside the circle. This can make Ryze outplay himself and get his entire team killed if proper vision is not set-up before the usage of the ability.
0 - 15 min
Focus on farming and getting as much gold and XP as possible. You need time and gold before you’re able to come online and deal damage.
Your champion is incredibly weak in the early game. Focus on farming and avoid fighting with the enemy until you’ve got an item behind you.
After your bot lane has moved to the mid lane, rotate to the bot side of the map or somewhere else on the map so you can continue to farm and gain XP. Do not fight anyone unless you have an advantage over them. Continue to get XP and gold.
15 - 25 min
At this stage of the game, you want to put yourself in a side lane and focus on farming so you have a stronger late game.
In the later parts of the mid-game and when the enemy starts to group, make sure you follow suit and start to group with your team.
Use your Ultimate R to get picks with your allies on enemies who are isolated or split up from their team. If you can catch someone out, try to take the Dragon or Baron afterwards.
25+ min
Stick with your team in the late game. Do not split up or walk away from them otherwise the enemy may try to pick you off or initiate a 4v5 fight when you’re away from your team.
Delay team fights while you dish out damage with your basic combos. Make sure you try to stay safe in team fights by watching your positioning and avoid overextending too much.
Ryze in the late game deals a lot of burst damage. Hide in high traffic areas if you’re ahead and look to blow someone up.
Ryze's weakness is quite staggering during the early game, so he should make sure that he plays safely and wards around carefully. The main goal is to scale up first.
His level six won't be very impactful during this phase of the game as it has a long cooldown, and roaming during this phase would be an issue.
The first item component will allow him to deal a lot of damage to his enemies and spam his abilities frequently. Still, he should not play too aggressively and just rely on scaling up.
Another point in his Ultimate R won't do him a lot of good either. It will allow him to rotate easily, but other than that, there is nothing much to it.
Ryze will have his core items now, which means he will be dishing out more damage than the early game. He has still not reached his final form yet, though.
Ryze will struggle during mid-game fights as his damage won't be enough to one-shot enemies. He will have to be careful about getting CC'd as well.
Ryze is excellent during the late game as he can completely take over the game with his overall burst damage combo and his Passive. All he needs to do is be a part of significant fights.
Level sixteen is a decent spike when it comes to macro-based plays. He can quickly jump from one objective to another, which can easily lead to wins for him.
His damage output will be really high during the later parts of the game. This will kill most of his enemies if they happen to get CC'd by Ryze.
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