Very versatile when it comes to builds and team comps. She can be both a tank destroyer, as well as a decimator of squishier champions depending on which build she opts for.
She is very strong when fighting in a 1 v 1 with no minions around. This is because her 
Q can all target the same champion and do a lot of damage in a short time.
Her 
E and Ultimate 
R allows her to be independent in the lane, while her Support roams around to get some kills or assists. Her Ultimate R can be used as a way to catch up and finish opponents as well, especially after they Flash or dash away from her.
Extremely vulnerable when her E is down as she can be an easy target to CC at that point. If she uses that ability carelessly, she will die a lot of times in the lane, as well as during team fights.
Improper positioning or aggressive usage of her Ultimate R can get her killed on multiple occasions. This can allow the enemy team to bait her in and get rid of her pretty quickly.
If she is set back during the early game, she won’t be able to come online as fast as her counterparts. As she is extremely item reliant, she will need to be peeled for as well.
0 - 15 min
Play safe for the first few levels. You need time to come online and you shouldn’t be fighting unless you have a clear early advantage (like an engage Support).
Once you have a few levels under your belt, you can start to look for aggressive plays. You benefit from extended trades, so try to go for them frequently.
After destroying the bottom lane tower, rotate to the mid lane and try to take that tower. This will open up the map and give your team a gold lead.
15 - 25 min
Stay with your Support throughout the mid-game. If you move away from them, you will be an easy target for the enemy. Make sure you’re always near at least 1 ally.
Group and stay with your team at all times. Do not split push or avoid grouping unless you have a good reason to be away from them.
Look for picks with your Support/Jungler to get kills and increase your lead. If you kill a key target, you could make the call for Baron.
25+ min
It is important that you stick with your team in the late game. Do not move around the map or go anywhere unless someone is with you.
Stand towards the back end of your team near your Support. Avoid walking too far away from anyone in the late game. Getting caught out will result in the enemy being able to push their advantage and finish the game.
Watch your positioning in the late game. Focus on kiting and auto-attacking the nearest enemy champion. Avoid walking too far forward so you do not get caught out and focused by the enemy.
The early game is a bit dependent on her Support. It becomes super easy for her to kill and chunk enemies when she is paired with a hard engage Support.
Unlocking her Q and E will give her a power spike in the lane. She can deal a lot of damage to her enemies in a very short time while using her E to be mobile and avoid CC.
A minor power spike is when she gets her 
W. The ability is quite impossible to dodge if it is aimed properly and will allow her to harass her enemies consistently.
Once she gets her core items, she will start dishing out a lot of damage in a very short while. The damage will also depend on whether she goes for the AP or AD build.
Her Passive will come in very handy during this stage of the game. Her Ultimate R will also let her perform kills on targets who are tagged by her but are trying to escape.
She may need to get a Stopwatch depending on which build she is going for. A Zhonya's Hourglass will help her preserve her power spikes if she is against an assassin heavy or CC heavy comp.
This phase of the game is her power phase. She is a monster and will shred through anyone if they come close to her and let Kai'sa pelt them for more than 2 seconds.
By this time all her abilities should be upgraded. This provides her with a lot of burst damage with a means to bamboozle enemies with her Q and Ultimate R. If she goes for the AP build, her W will start hitting like a truck.
Fighting in open areas is best for her as she can kite well and can 1 v 2 or 1 v 3 enemies. When fighting in close areas she will always have to be behind her frontline or else she will not survive for too long.
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