Very versatile when it comes to builds and team comps. She can be both a tank destroyer, as well as a decimator of squishier champions depending on which build she opts for.
She is very strong when fighting in a 1 v 1 with no minions around. This is because her 
Q can all target the same champion and do a lot of damage in a short time.
Her 
E and Ultimate 
R allows her to be independent in the lane, while her Support roams around to get some kills or assists. Her Ultimate R can be used as a way to catch up and finish opponents as well, especially after they Flash or dash away from her.
Extremely vulnerable when her E is down as she can be an easy target to CC at that point. If she uses that ability carelessly, she will die a lot of times in the lane, as well as during team fights.
Improper positioning or aggressive usage of her Ultimate R can get her killed on multiple occasions. This can allow the enemy team to bait her in and get rid of her pretty quickly.
If she is set back during the early game, she won’t be able to come online as fast as her counterparts. As she is extremely item reliant, she will need to be peeled for as well.
0 - 15 min
Play safe for the first few levels. You need time to come online and you shouldn’t be fighting unless you have a clear early advantage (like an engage Support).
Once you have a few levels under your belt, you can start to look for aggressive plays. You benefit from extended trades, so try to go for them frequently.
After destroying the bottom lane tower, rotate to the mid lane and try to take that tower. This will open up the map and give your team a gold lead.
15 - 25 min
Stay with your Support throughout the mid-game. If you move away from them, you will be an easy target for the enemy. Make sure you’re always near at least 1 ally.
Group and stay with your team at all times. Do not split push or avoid grouping unless you have a good reason to be away from them.
Look for picks with your Support/Jungler to get kills and increase your lead. If you kill a key target, you could make the call for Baron.
25+ min
It is important that you stick with your team in the late game. Do not move around the map or go anywhere unless someone is with you.
Stand towards the back end of your team near your Support. Avoid walking too far away from anyone in the late game. Getting caught out will result in the enemy being able to push their advantage and finish the game.
Watch your positioning in the late game. Focus on kiting and auto-attacking the nearest enemy champion. Avoid walking too far forward so you do not get caught out and focused by the enemy.
Kai’Sa’s early game strength depends on the Support synergy. When paired with all-in champions, she will be good in the early game.
Her level 6 power spike is pretty useful. She can use her Ultimate R to reposition, engage and disengage from fights, and protect herself.
When Kai’Sa has purchased her first component item, her damage output will increase. She will be better at skirmishing and trading with the enemy too.
At level nine, her Q will be completely maxed out and deal a lot of damage to her enemies. This will let her take over the game with ease.
Depending on which build she is going for, she will be getting her first ability upgrade during this stage of the game. This will be a massive power spike and will let her be the prime carry for her team.
Kai'sa is really good in fights due to her E and Q. She can peel for herself and use her Ultimate R for both aggressive and defensive purposes.
Once Kai'Sa gets three points in her Ultimate R, she will have a massive shield and can reposition instantly if things go awry during fights.
She will have many upgraded abilities during this phase of the game. This means that her damage output, as well as her defensive ability, will be really high.
At level 13, she will have two abilities wholly maxed out. This means her damage output with her Q, and her peel potential with her E will be massive.
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