This comp is very similar to the Dawnbringer Karma comp except that is uses more Brawlers and transitions with them as well. This provides a strong frontline for Karma to ramp up her ability.
Go for this comp if you have good Karma items and start with Brawler units.
Level up to 4 early if you want to start a win streak. Level up to 5 to try and continue the streak.
If you're weak in the early game, you can opt to save gold and lose streak instead.
At Round 2, level up to 6 regardless of your start. Put together the strongest team you can.
At Round 1, level up to 7. Roll down to stabilize your comp if you are weak. Afterward, save up to hit level 8 and complete your comp.
Blue Buff is absolutely mandatory on Karma. Jeweled Gauntlet is her best damage item. After that, you can use any item you can build in place of Shadow Rabadon's. This can be something like more damage with HoJ or Infinity Edge or healing with Hextech Gunblade.