Vayne vs Cassiopeia

Get everything you need for Vayne Mid build! The highest win rate Vayne runes, items, skill order and summoner spells in patch 13.6.

Tier	D-
Win rate	48.6%
Pick rate	0.2%
Ban rate	7.9%
Matches	4 059-

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Vayne matchups

Mid ∙ Patch 13.6

Vayne counter tips

Matchup specific advice on how to play against Vayne as Cassiopeia

best picks
vs Vayne

worst picks
vs Vayne

These champs are strong against Vayne at most phases of the game. They’re listed based on their win rate against Vayne.

Champion

Matches

Guide

Overall Average

Twisted Fate

Vladimir

Zoe

Kassadin

Qiyana

Syndra

Viktor

Vex

Yone

LeBlanc

Akshan

Ahri

Annie

Lissandra

Yasuo

For matchups that are not listed above, check the matchups table

Vayne

54.5% Win Rate

Cassiopeia

45.5% Win Rate

Matchup stats based on the 33 matches

2.19

KDA

2.04

-121

G@15

121

6.6

CS/M

6.9

42%

41%

724.4

DPM

681.5

1.7

Avg. Solo Lane Kills

1.4

1.8

Effective Roams

2.3

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Vayne Matchups Table

Rank	Champion	WR	Delta	GD@15	XPD@15	CSD@15	LVL2	Matches


1	Twisted Fate	81.1%	29.5%	806.8g	511.6xp	1.4	48.6%	37


2	Vladimir	63.6%	12.1%	474.3g	937.7xp	13.3	49.1%	55


3	Zoe	61.3%	9.7%	156.6g	172.5xp	-0.8	48.4%	31


4	Kassadin	60.3%	8.8%	-398.3g	119.4xp	-10.2	27.0%	63


5	Qiyana	60.0%	8.4%	542g	616.3xp	1.8	42.9%	35


6	Syndra	59.6%	8.1%	337.3g	660.9xp	12.9	55.8%	52


7	Viktor	59.3%	7.8%	286.5g	672.3xp	14.1	39.6%	91


8	Vex	58.5%	6.9%	203.9g	340.1xp	-2.1	34.0%	53


9	Yone	58.2%	6.7%	148.6g	547.3xp	3	47.3%	91


10	LeBlanc	56.1%	4.6%	793.9g	683.8xp	3.5	40.4%	57