After recalling, Twitch can enter the lane in stealth with his Q. Avoid pushing up too far when you know Twitch has just backed as he may pop up and go for a favourable trade.
Twitch benefits from extended trades. Try to go for short bursty trades over long ones with him when possible.
If Twitch has pushed the wave and left lane, he is either trying to bait you forward and go for a trade, or he has gone to the mid lane with his Support. Have consistent vision around your lane so you know what he’s doing and where he’s going.
Don't clump up or stick close together in team fights versus Twitch as his Spray and Pray R will melt you. Spread out and look for a way to burst him down once he reveals himself.
Twitch will often get incredibly close to your team after popping out of his Q. Once he has left it, try to take him down as quickly as you can.
Control Wards are essential in team fights. Place Trinkets and Control Wards around you when sieging an objective to spot Twitch before he is able to jump out on you.
Twitch is a hyper carry and will become stronger and stronger as the game goes on. Ending the game quickly is often the wisest choice when playing against him.
Once he has access to his Ultimate R, his kill pressure increases. It’s extended range and damage: in conjunction with his Q, can be hard to deal with in lane.
Once Twitch has got Runaan's Hurricane, his damage output will be deadly. It is very important that you do not let him dish out his damage by bursting him down at the start of the fight.