Ensure there is always a minion between you and Pyke at all times to make it harder for him to land his Q.
Keep an eye on his positioning at all times. Try and stay at max distance whenever possible to make it even harder for him to land his Q.
Pyke is a great roaming champion. Once he gets Mobility Boots, expect him to roam frequently. Ping whenever he leaves lane so your teammates know that he is missing.
Back away when you’re low on HP in a team fight so he is unable to get the reset on his Ultimate R. Similarly, make sure you use Flash to escape his Ultimate R so he cannot get the reset and win the fight.
Ward the flanks when sieging objectives as Pyke can attack from the side or pick someone off with his Q and win the fight.
Locking Pyke down with CC as soon as he engages will make it really difficult for him to deal damage and execute anyone.
Pyke is strong at level 1 and 2. Ensure you hit level 2 at the same time or before him to reduce his ability to get an early kill.
Once Pyke hits level 6, his kill pressure increases as his Ultimate R is an execute. Back away when low so he is unable to kill you and snowball his lead.
Pyke is really good at roaming. Once he has Mobi Boots, expect him to roam around the map and assist his allies. Ping whenever he goes missing.