When playing melee champions, do not let Lulu bully you down with auto-attacks. When you’re not looking to engage, stand back so she cant auto-attack you.
Waiting for Lulu to use her E before fighting or poking is a good way of coming out ahead. Try to bait this ability out and then play aggressive while it’s on cooldown.
Post 6 and when Lulu gets her Ultimate R, her survivability increases a lot. Keep in mind that it’s going to be difficult for you to kill her when her Ultimate R is up. Do not commit to the all-in unless it’s down or she’s out of mana.
In team fights, try to catch Lulu out of position or lock her down with CC. If you can take her down first, her ability to protect her ADC and her carries will be lessened. If you can’t kill her, you might be able to force herself to self-cast her Ultimate R.
Lulu will often go to ward alone. You can look to ambush her and take her down while she’s isolated and then start a team fight with her team while she’s dead.
For AD champions, invest in an Executioner's Calling when Lulu and her team is ahead. This will reduce her healing and shielding capability on her allies.
Lulu is strong at level 6 as her Ultimate R provides tons of utility and increases her or her ADC’s survivability.
Once Lulu has completed her first item, her protection and shielding ability will increase dramatically. At this stage, she will also do a hefty amount of damage when trading.
Lulu is very good in team fights as she will build items that buff her team up. Try and lock her down with CC or kill her when she goes to ward so she is unable to affect the team fight.