At 3, 5, and 7, Mutants gain a different Trait bonus from game to game. Cybernetic Enhancement grants bonus stats to Mutants with at least 1 item. Voracious Appetite strengthens Mutants on each ally's death. Voidborne executes targets below a Health threshold and deals true damage. Hyper-Adrenal Glands give a chance for Mutants to deal additional attacks. Synaptic Web reduces the Mana cost of Mutants’ Abilities. Bio-Leeching grants Omnivamp (healing for a percentage of damage dealt) to your team. Metamorphosis grants stacking bonuses to Mutants at regular intervals.

Challengers get bonus Attack Speed. Upon scoring a takedown, Challengers dash to a new target and double this bonus for 2.5 seconds.