Zyra is really good at poking. Opt for extra sustain through Biscuit Delivery if you’re taking Inspiration and make sure you take flat magic resistance early.
Zyra is very squishy and can easily be killed if focused down. Communicate with your team to get ganks and shut her down early.
Zyra’s Plants deal a lot of damage in the later stages of the laning phase. Avoid staying in range of them for too long because the damage does stack up quickly.
When she goes to ward objectives, ambush her and take her down before the team fight starts so the enemy lacks crowd control and damage. This can help swing the team fight in your favour.
Zyra will look to hide in bushes and wait for you to walk fast before trying to one shot you. Try to keep your camera on yourself so you do not get surprised. Additionally, try to stick to warded areas rather than walking through the unknown.
Zyra will use her on herself as soon as your team engages on her. Try to keep this in mind when using dashes as you will get knocked up by her Ult. Save your dashes unless she has already activated her beforehand.
Zyra is really potent in lane when she has multiple saplings around her. This is due to the fact that those plants can spring into action and start dealing damage to you if you’re near them.
She is rather strong at level 3 and 6 as those levels are when she is given additional abilities. Take great care and be prepared for her to all in as she gets the level up.
Zyra gets stronger as the game goes on because it gives her enough time to come online and purchase her core items. Once she has got Liandry's and Morello’s she will hit like a truck.