Lissandra’s is her only source of wave clear in lane (as she has to keep her to stay safe). Whenever she uses it, push back the wave as fast as possible to not get pushed under tower.
Lissandra’s has a huge cooldown (almost 20 seconds). If she uses it, it opens up a great gank or trade window that you can use to take her out of the lane
Always take Cleanse if you’re laning against Lissandra. When she hit 6 she can CC you for 2 seconds + slow. Cleanse her so she can’t connect every other spell afterwards.
Lissandra’s Passive deals huge damage and brings a lot of CCs in teamfights, but to proc it, someone has to die! If someone of your team is low before a teamfight, back away or she can clear the whole team fight easily
Lissandra will most likely want to dive into the back lane and use her and Zhonya’s combo. If you’re a carry, stay far from Lissandra’s so she cannot burst you down. Punish her as soon as she comes out of her or Zhonya.
Lissandra is a very good split pusher, but she has a lot of trouble dueling tanks. If she goes for a split push, be sure to send someone that can duel her easily.
When Lissandra hits level 6 she can burst down any squishy target and it gives her an easy follow up for ganks. Therefore you should be very careful at the moment she gets her level 6 and ward deep to not get Flash Ulted by Lissandra with the Jungler.
Her Protobelt gives her a new dash, more wave clear and more burst. This item gives her many options so you have to play extra careful
Lissandra reaches her true potential when teamfighting as it is the only way she can use her Passive. If you can, try to take her out before the teamfight begins.